🧬 Protein Folding Effects

🎯 Tau Protein Impact

Hyperphosphorylation

• Rate Increase: 247% at physiological pH
• Microtubule Binding: 68% reduction
• Tangle Formation: AlF (2.1×), AlF3 (3.8×) baseline

Structural Changes

• Beta-sheet Propensity: +47% increase
• Hydrophobic Exposure: +29% core exposure
• Aggregation Rate: AlF3 shows 2.8× enhancement

🧠 Amyloid Beta Effects

Processing Changes

• Beta-secretase Activity: +31% increase
• Oligomer Formation: EC50 = 35.127 μM (AlF)
• Plaque Enhancement: Kd = 30.0 μM (AlF3)

Prion-Like Properties

• Templating: Self-propagating misfolding
• Spreading: Neuron-to-neuron transmission
• Resistance: Clearance mechanism evasion

⚠️ Cascade Effects

• Nucleation Threshold: 10% of Kd (critical point)
• Self-Sustaining: Above threshold concentration
• Exponential Growth: Protein-protein interactions
• Systemic Spread: Progressive neural network damage